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First published on April 28, 2008
Clinical and Applied Thrombosis/Hemostasis 2008, doi:10.1177/1076029608316013

Article

Association of Angiotensin-Converting Enzyme Gene 2350 G>A Polymorphism With Myocardial Infarction in a Chinese Population

Min Pan, Min-Hui Jiang, Mei-Fang Wei, Zhi-Hua Liu, Wen-Ping Jiang, Hai-Hua Geng, Zhi-Chu Cui, Dong-Lei Zhang, and Jian-Hua Zhu*

* To whom correspondence should be addressed. E-mail: zhjhntdx{at}163.com.


  Abstract
Angiotensin-converting enzyme (ACE) gene 2350G>A polymorphism has the most significant effect on plasma ACE concentrations. But the association between this polymorphism and myocardial infarction (MI) is presently unknown. We carried out a case-control study in the Chinese Han population. ACE2350G>A genotypes of 231 patients with MI and 288 healthy controls were detected by PCR-RFLP. Differences in frequencies of ACE genotypes and alleles and their associations with clinical features were assessed. The distribution of the ACE2350G>A genotypes (GG, GA, and AA) was 20.78%, 51.08%, and 28.14% in the MI group and 31.60%, 46.53%, and 21.87% in controls, respectively (P = .0167).The frequency of the A allele in the MI group was significantly higher than that in controls (53.68% vs 45.14%, P = .0062). The A allele carriers (GA + AA genotypes) had approximately 2-fold increased risk of MI when compared with the GG genotype (odds ratio = 1.76; 95% confidence interval = 1.24-3.52). There were no significant differences among the 3 genotypes in plasma levels of lipids, apolipoproteins, high-sensitivity C-reactive protein, and soluble CD40 ligand in either the MI group or the control group (P > .05). No statistical difference was observed between ACE2350G>A polymorphism and severity of the coronary lesions (P > .05). These results suggest that ACE2350G>A polymorphism is associated with acute MI, and A allele carrier is an independent risk factor for acute MI in the Chinese Han population.


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