Clinical and Applied Thrombosis/Hemostasis

 

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This version was published on July 1, 2008
Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 3, 279-285 (2008)
DOI: 10.1177/1076029607309176

Elevated Levels of Prothrombin Fragment 1 + 2 Indicate High Risk of Thrombosis

Satoshi Ota, MD, PhD

Department of Cardiology, Mie University Graduate School of Medicine

Hideo Wada, MD, PhD

Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, wadahide{at}clin.medic.mie-u.ac.jp

Yasunori Abe

Department of Central Laboratory, Mie University Graduate School of Medicine

Eri Yamada

Department of Central Laboratory, Mie University Graduate School of Medicine

Akane Sakaguchi

Department of Central Laboratory, Mie University Graduate School of Medicine

Junji Nishioka, PhD

Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine

Tsuyoshi Hatada, MD, PhD

Department of Emergency Medicine, Mie University Graduate School of Medicine

Ken Ishikura, MD, PhD

Department of Emergency Medicine, Mie University Graduate School of Medicine

Norikazu Yamada, MD, PhD

Department of Cardiology, Mie University Graduate School of Medicine

Akihiro Sudo, MD, PhD

Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie-ken, Japan

Atsumasa Uchida, MD, PhD

Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie-ken, Japan

Tsutomu Nobori, MD, PhD

Department of Cardiology, Mie University Graduate School of Medicine

Prothrombin fragment 1 + 2 (F1 + 2) is considered to be useful for diagnosis of thrombosis. However, the evidence for a diagnosis of thrombosis by F1 + 2 is still not well established. The plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were measured in 694 patients suspected of having thrombosis and then were correlated with thrombosis. Plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were significantly higher in patients with thrombosis, compared with patients without thrombosis. When cutoff values of more than 300 pmol/L for F1 + 2 were used for the diagnosis, more than 50% of the patients were thus found to have thrombosis. The findings showed that F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex have similar diagnostic ability. The plasma concentration of F1 + 2 closely was well correlated with thrombin-antithrombin complex, soluble fibrin, and D-dimer. Finally, F1 + 2 is one of the most useful parameters for the diagnosis of thrombosis.

Key Words: thrombosis • F1 + 2 • SF • D-dimer • TAT


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